Bacterial swarming is a mode of motion in which dense collectives of rod-shaped flagellated cells migrate rapidly on surfaces. The transition into swarming involves several cellular processes, including changes in cell aspect ratio, suggesting that bacteria manipulate these properties in order to promote physical conditions that are favorable for swarming. New results with monolayer swarms of Bacillus subtilis with different aspect ratios were analyzed at different cell-densities. A comprehensive analysis of the individual and collective dynamics of bacteria in a swarm brings forth a phase diagram, showing sharp transitions between phases corresponding to qualitatively different swarm statistics. From a biological perspective, we find that under standard conditions bacteria inhabit a region of phase space in which the swarm dynamics is highly robust and insensitive to fluctuations. In this regime, bacteria do not form very large clusters and lack global orientational order, properties which may reduce the colony's ability to expand rapidly in the absence of external directional cues.
Monday, June 14 at 09:30am (PDT)Monday, June 14 at 05:30pm (BST)Tuesday, June 15 01:30am (KST)
MS01-CBBS: Mathematical modeling of emergent phenomena in cell colonies
Organized by: Shawn D. Ryan (Cleveland State University, United States), Mykhailo Potomkin (UC Riverside, United States), Jia Gou (UC Riverside, United States) Note: this minisymposia has multiple sessions. The second session is MS02-CBBS.
- Gil Ariel (Bar Ilan University, Israel) "A Phase Diagram for Bacterial Swarming"
- Fernando Peruani (CY Cergy Paris University, France) "A mathematical approach to bacterial infections: models for bacterial exploration, aggregation, and infection"
- Silke Henkes (University of Bristol, United Kingdom) "Flow, fluctuate, freeze: Cell sheets as soft active matter"
- Kevin Painter (Politecnico di Torino, Italy) "Sticking together by going against the flow"
MS01-CDEV: Data-driven modeling across scales - from cytoskeleton to bacterial swarms to multicellular motility to angiogenesis
Organized by: Alex Mogilner (NYU, United States), Angelika Manhart (UCL, UK)
- Angelika Manhart (UCL, United Kingdom) "Explaining the dynamic steady state of actin networks"
- Hannah Jeckel (University of Marburg, Germany) "Learning the space-time phase diagram of bacterial swarm expansion"
- Dhananjay Bhaskar (Yale and Brown Universities, USA) "Discrete Agent Modeling and Topological Data Analysis of Self-Organized Multicellular Architectures"
- John Nardini (NC State University, USA) "Topology discriminates parameter regimes in a model of angiogenesis"
MS01-DDMB: Stochastic models of cancer: An update of theory and data
Organized by: Marek Kimmel (Rice University, United States), Simon Tavare (Columbia University, United States) Note: this minisymposia has multiple sessions. The second session is MS02-DDMB.
- Tibor Antal (School of Mathematics, Edinburgh University, Scotland, UK, UK) "Models of Tumor Progression"
- Robert Beckman (Lombardi Comprehensive Cancer Center and Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA, USA) "Recent Advances in Genetic Instability and Dynamic Precision Medicine of Cancer"
- Alexandre Bouchard-Côté (Statistics, University of British Columbia, Vancouver, BC, Canada, Canada) "Inferring fitness of cancer subpopulations from time series --- Bayesian methods for the Wright-Fisher diffusion with selection"
- Ivana Bozic (Applied Mathematics, University of Washington, Seattle, WA, USA, USA) "Mathematical model of colorectal cancer initiation"
MS01-ECOP: Mathematical modeling of gene drives
Organized by: Gili Greenbaum (The Hebrew University of Jerusalem, Israel), Jaehee Kim (Cornell University, USA) Note: this minisymposia has multiple sessions. The second session is MS06-ECOP.
- Marcus Feldman (Stanford University, USA) "The antecedents of modern gene-drive models: Some history of meiotic drive models"
- Chaitanya Gokhale (Max Planck Institute for Evolutionary Biology, Germany) "Synthetic gene drives and the control problem"
- Philipp Messer (Cornell University, USA) "Suppression gene drive in continuous space can result in unstable persistence of both drive and wild‐type alleles"
- John Marshall (University of California Berkeley, USA) "Modeling priorities as gene drive mosquito projects transition from lab to field"
MS01-EDUC: Highlights of the Special Issue of BMB on Mathematical Biology Education
Organized by: John R Jungck (University of Delaware, USA), Raina Robeva (Randolph Macon College, USA), Louis Gross (University of Tennessee, USA) Note: this minisymposia has multiple sessions. The second session is MS02-EDUC.
- Midge Cozzens (Rutgers University, USA) "Introductory College Mathematics for the Life Sciences: Has Anything Changed?"
- Melissa Aikens (University of New Hampshire, USA) "Advances and Challenges in Undergraduate Biology Education"
- Raina Robeva (Randolph Macon College, USA) "Changing the Nature of Quantitative Biology Education: Data Science as a Driver"
- Padmanabhan Seshaiyer (George Mason University, USA) "Conneccting with teachers through Modeling Mathematical Biology"
MS01-EVOP: Non-equilibrium Thermodynamics in Biology: from Chemical Reaction Networks to Natural Selection
Organized by: John Baez (University of California, Riverside, USA), William Cannon (Pacific Northwest National Laboratory, USA), Larry Li (University of California, Riverside, USA) Note: this minisymposia has multiple sessions. The second session is MS02-EVOP.
- John Harte (University of California, Berkeley, USA) "Nonequilibrium dynamics of disturbed ecosystems"
- Hong Qian (University of Washington, USA) "Large deviations theory and emergent landscapes in biological dynamics"
- Pierre Gaspard (Université libre de Bruxelles, Belgium) "Nonequilibrium biomolecular information processes"
- Carsten Wiuf (University of Copenhagen, Denmark) "Reduction and the Quasi-Steady State Approximation"
MS01-IMMU: Mathematical tools for understanding viral infections within-host and between-host
Organized by: Hana Dobrovolny (Texas Christian University, United States), Gilberto Gonzalez-Parra (New Mexico Tech, United States) Note: this minisymposia has multiple sessions. The second session is MS02-IMMU.
- Guang Lin (Purdue University, United States) "Predicting the COVID-19 pandemic with uncertainties using data-driven models"
- Ana Vivas-Barber (Norfolk State University, United States) "Using Seasonality and Variable Incubation Periods to Study the Impact of Including Domestic Animals on the Dynamics of Malaria Transmission"
- Imelda Trejo Lorenzo (Los Alamos National Laboratory, United States) "A modified Susceptible-Infected-Recovered model for observed under-reported incidence data"
- Naveen Vaidya (San Diego State University, United States) "Modeling the risk of SARS-CoV-2 transmission from fomites"
MS01-MEPI: From Primate to Vectors to Humans: Understanding the underlying mechanisms of disease transmission and control
Organized by: Folashade Agusto (University of Kansas, United States), Majid Bani Yaghoub (University of Missouri Kansas City, United States) Note: this minisymposia has multiple sessions. The second session is MS02-MEPI.
- Amy Goldberg (Duke University, United States) "Model-based estimates of zoonotic malaria spillover in Atlantic Forest, Brazil"
- Ibrahim M. ELMojtaba (Sultan Qaboos University, Oman) "The role of primates and human movement on the dynamics of zika virus"
- Omar Saucedo (Virginia Polytechnic Institute and State University, United States) "Tick-borne Diseases in Virginia"
- Sean Cavany (University of Notre Dame, United States) "The impacts of COVID-19 mitigation on dengue virus transmission: a modelling study"
MS01-MFBM: Mathematical Modeling Applied to Pharmaceutical Sciences Problems
Organized by: Carl Panetta (St. Jude Children's Research Hospital, US), Helen Moore (Laboratory for Systems Medicine, University of Florida, US)
- C.J. Musante (Pfizer, US) "A Few Open Mathematical Modeling Problems in Drug Discovery & Development"
- Jane Bai (FDA, US) "Conducting sensitivity analysis and uncertainty analysis for QSP needs more than mathematical computation"
- Freya Bachmann (Department of Mathematics and Statistics, University of Konstanz, Germany) "Computing the Individualized Optimal Drug Dosing Regimen Using Optimal Control"
- Tongli Zhang (Department of Pharmacology & Systems Physiology, College of Medicine, University of Cincinnati, US) "Coping with the Challenge of Heterogeneity with Integrated Modeling, Machine Learning, and Dynamical Analysis"
MS01-MMPB: Mathematical Modeling of Blood Clotting: From Surface-Mediated Coagulation to Fibrin Polymerization
Organized by: Karin Leiderman (Colorado School of Mines, United States), Anna Nelson (University of Utah, USA) Note: this minisymposia has multiple sessions. The second session is MS07-MMPB.
- Anna Nelson (University of Utah, USA) "Understanding the effect of fibrinogen interactions on fibrin gel structure"
- Michael Kelley (Colorado School of Mines, USA) "Modeling the effects of bivalently bound thrombin on fibrin polymerization"
- Francesco Pancaldi (University of California Riverside, USA) "Modeling study of clot contraction"
- Sumith Yesudasan (Sam Houston State University, USA) "Coarse-grained Molecular Model for Fibrin Polymerization"
MS01-NEUR: Mathematical neuroscience
Organized by: Sunil Modhara (University of Nottingham, United Kingdom), Stephen Coombes (University of Nottingham, United Kingdom), Ruediger Thul (University of Nottingham, United Kingdom), Daniele Avitabile (Vrije Universiteit Amsterdam, Netherlands)
- Sunil Modhara (University of Nottingham, United Kingdom) "Neural fields with rebound currents: novel routes to patterning"
- Louisiane Lemaire (Inria Sophia Antipolis Méditerranée Research Centre, France) "Mathematical model of the mutations of a sodium channel (NaV1.1) capturing both migraine and epilepsy scenarios"
- Manu Kalia (University of Twente, Netherlands) "Modeling ischemic vulnerability at the tripartite synapse"
- John Rinzel (New York University, USA) "A neuronal model for learning to keep a rhythmic beat"
MS01-ONCO: Mathematical approaches to advance clinical studies in oncology
Organized by: Heyrim Cho (University of California Riverside, USA), Russell Rockne (City of Hope Comprehensive Cancer Center, USA) Note: this minisymposia has multiple sessions. The second session is MS02-ONCO.
- Hitesh Mistry (University of Manchester, UK) "Complexity/Simplicity of Oncology Pharmacodynamic Markers/Mathematical Models in the Clinic versus Drug Development"
- Renee Brady (H. Lee Moffitt Cancer Center and Research Institute, USA) "Predicting Response to Adaptive Therapy in Metastatic Prostate Cancer Using Prostate-Specific Antigen Dynamics"
- Aleksandra Karolak (City of Hope Comprehensive Cancer Center, USA) "A Quantitative Systems Pharmacology Model to Improve Graft Versus Host Disease Outcomes"
- Kit Curtius (University of California San Diego, USA) "Predicting Risk of Progression to Advanced Neoplasia in Patients with Ulcerative Colitis"