Tumor-Immune Dynamics and Oncolytic Virotherapy
Tuesday, June 15 at 11:30am (PDT)Tuesday, June 15 at 07:30pm (BST)Wednesday, June 16 03:30am (KST)
Lisette dePillis (Department of Mathematics, Harvey Mudd College, United States), Amina Eladdadi (Department of Mathematics, The College of St. Rose, United States)
Oncolytic viruses (OVs) have emerged as a novel and promising immunotherapeutic strategy against advanced cancer that may be further combined with existing therapeutic modalities to enhance effectiveness. Predicting the outcome of tumor virotherapy is a challenge since the system responses to OV treatment are complex. One of the major challenges involves understanding the immune system’s response to the virus, which diminishes the effects of oncolytic virotherapy by facilitating viral clearance. While incredible efforts have been made over the past decades to decipher the complexity of tumour–immune interactions, the dynamics of oncolytic viral tumor infection and the consequences of OV induced immune response are still poorly understood. In the quest to better understand the complex dynamics involved with OV therapy, mathematical models can be used to address specific questions regarding disease progression, immune activation, and pathologies. In this session, we will bring together applied mathematicians working in the areas of tumor-immune dynamics and virotherapy treatments to present current discoveries.