The “shock and kill” strategy has become a promising way to cure HIV by eliminating latent HIV reservoirs, the main barrier to a clinical cure. Recently, single-cell screening experiments have shown the Noise-enhanced drug synergy on reactivating latent HIV. However, the underlying biomolecular mechanism is still a mystery. We propose here a generic model for HIV regulation and Tat transcription/translation. Using this model, we find out that the drug synergy is mainly determined by the magnitude and direction of energy input into the genetic regulatory kinetics of HIV promotor. We further show that the Noise-enhanced drug synergy requires the timescale of HIV promoter entering into a transcriptionally non-permissive state without drugs presented to be slower than the timescale of Tat transactivation. Our model reveals a generic nonequilibrium mechanism underpinning the Noise-enhanced drug synergy, which is useful for improving the drug effect and identifying other drug synergies on lentivirus latency reactivation.
Tuesday, June 15 at 05:45pm (PDT)Wednesday, June 16 at 01:45am (BST)Wednesday, June 16 09:45am (KST)
MS09-CBBS: Modeling and data analysis of dynamics from molecules, cells to populations
Organized by: Lei Zhang (Peking University, China) Note: this minisymposia has multiple sessions. The second session is MS10-CBBS.
- Hao Ge (Peking University, China) "The Nonequilibrium Mechanism of Noise-Enhanced Drug Synergy in HIV Latency Reactivation"
- Yusuke Imoto (Kyoto University, Japan) "Topological Trajectory Inference for Single-cell RNA Sequencing Data"
- Suoqin Jin (University of California Irvine, U.S.) "Understanding the role of cell-cell communication in cell fate decisions from single-cell data"
- Dae Wook Kim (Korea Advanced Institute of Science and Technology, Korea) "Moment-based inference of cell-to-cell variability in signal transduction time"
MS09-DDMB: Machine Learning and Data Science Approaches in Mathematical Biology: Recent Advances and Emerging Topics
Organized by: Paul Atzberger (University of California Santa Barbara, USA), Smita Krishnaswamy (Yale University, USA), Kevin Lin (University of Arizona, USA) Note: this minisymposia has multiple sessions. The second session is MS08-DDMB.
- Zhuo-Cheng Xiao (Courant Institute, NYU) "A data-informed mean-field approach to mapping cortical landscapes"
- Andrea Arnold (Worcester Polytechnic Institute, USA) "Data Assimilation for Time-Varying Parameter Estimation in Biological Systems"
- John Fricks (Arizona State University, USA) "A Bayesian Analysis of 2-D Motor-Cargo Complex Dynamics"
- Mengyang Gu (University of California, Santa Barbara, USA) "Uncertainty quantification and estimation in differential dynamic microscopy for biomaterials characterization"
MS09-ECOP: Spatial approaches to ecological population monitoring and management
Organized by: Tae-Soo Chon (Pusan National University/Ecology and Future Research Association, Republic of Korea), Fugo Takasu (Nara Women’s University, Japan) Note: this minisymposia has multiple sessions. The second session is MS10-ECOP.
- Tae-Soo Chon (Ecology and Future Research Institute/Pusan National Univ., Republic of Korea) "Patterning local cooccurrence patterns of Nutria individuals using Geo-self-organizing map applied to telemetry data"
- Thakur Dhakal (Kangwon National Univ., Republic of Korea) "Unraveling Behavior States of Wild Boar Movements in Habitat Transitions Using Hidden Markov Model"
- Sung-Won Hong (Kyungpook National Univ., Republic of Korea) "Ensemble species distribution models proved habitat characteristics coincidence of dead and living long-tailed gorals (Naemorhedus caudatus) according to extreme snowfall"
- Taeyong Shim (Korea University, Republic of Korea) "Evaluating Distribution Shifts of Invasive Largemouth Bass under Climate Change"
MS09-EVOP: The Study of Diffusive Dispersal in Population Dynamics
Organized by: Chiu-Yen Kao (Claremont McKenna College, United States), Bo Zhang (Oklahoma State University, United States) Note: this minisymposia has multiple sessions. The second session is MS08-EVOP. The third session is MS10-EVOP.
- Rachidi Salako (University of Nevada at LasVegas, United States) "Study of a diffusive multiple-strains epidemic model"
- Kurt Anderson (Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, United States) "Body size dependent dispersal influences stability in heterogeneous metacommunities"
- Harunori Monobe (Okayama University, Japan) "Singular limit of a mathematical model related to controlling invasive alien species"
- King-Yeung Lam (Department of Mathematics, The Ohio State University, United States) "Defining the Ideal Free Distribution in Spatio-temporally Heterogeneous Environments."
MS09-IMMU: Within-host modelling of SARS-CoV-2
Organized by: Thomas Hillen (University of Alberta, Canada), Carlos Contreras (University of Alberta, Canada) Note: this minisymposia has multiple sessions. The second session is MS10-IMMU.
- Morgan Craig (Sainte-Justine University Hospital Research Centre/Université de Montréal, Canada) " The impact of viral variants on immunopathology in COVID-19"
- Ashlee N. Ford Versypt (University at Buffalo, The State University of New York, USA) "Multiscale Simulation of Lung Fibrosis Induced by SARS-CoV-2 Infection and Acute Respiratory Distress Syndrome"
- Paul Macklin (Indiana University, USA) "Community-driven multiscale model of SARS-CoV-2 dynamics and immune response"
- Adrianne Jenner (Queensland University of Technology, Australia) "Virtual patient cohort reveals immune mechanism driving COVID-19 disease outcomes"
MS09-MEPI: Advances in Infectious Disease Modeling
Organized by: Lihong Zhao (University of California Merced, United States), Ling Xue (Harbin Engineering University, China), Suzanne Sindi (University of California Merced, United States) Note: this minisymposia has multiple sessions. The second session is MS08-MEPI.
- Steve Krone (Department of Mathematics and Statistical Sciences, University of Idaho, United States) "The Timing and Nature of Behavioral Responses Affect the Course of an Epidemic"
- Skylar Grey (University of Wisconsin Madison) "Contact Tracing during an Ebola Outbreak"
- Lihong Zhao (Department of Applied Mathematics, University of California Merced, United States) "Association of Microbiome Dynamics with Chlamydia Infection"
- Xiaotian Wu (College of Arts and Sciences, Shanghai Maritime University, China) "Modelling Triatomine Bug Population and Trypanosoma Rangeli Transmission: Co-feeding, Pathogenic Effect and Linkage with Chagas Disease"
MS09-MFBM: Emergent behavior across scales: locomotion, mixing, and collective motion in active swimmers
Organized by: Robert Guy (University of California Davis, United States), Arvind Gopinath (University of California Merced, United States) Note: this minisymposia has multiple sessions. The second session is MS15-MFBM.
- Henry Fu (University of Utah, United States) "Symmetry breaking propulsion of magnetically rotated spheres in nonlinearly viscoelastic fluids"
- Kathryn Link (University of California Davis, United States) "Emergent Properties of Flagellar Waveforms in Viscoelastic Fluids"
- Rudi Schuech (Tulane University, United States) "Viscoelastic Network Remodeling by Microswimmers"
- Sookkyung Lim (University of Cincinnati, United States) "Simulations of microswimmers propelled by multiple flagella"
MS09-MMPB: Multiscale simulations of biological fluid dynamics
Organized by: Matea Santiago (University of California, Merced, United States), Shilpa Khatri (University of California, Merced, United States) Note: this minisymposia has multiple sessions. The second session is MS08-MMPB.
- Lindsay Waldrop (Assistant professor, Chapman University, United States) "The effects of circulatory resistivity on performance of transport by systems with tubular, peristaltic hearts"
- Laura Miller (Departments of Mathematics and Biomedical Engineering, University of Arizona, United States) "Slow and fast airflow past Saguaro and other cacti"
- Shilpa Kharti (Department of Applied Mathematics, University of California, Merced, United States) "Pulsing Soft Corals"
- Matea Santiago (Department of Applied Mathematics, University of California, Merced, United States) "Soft Corals: Pulsing, Mixing, and Photosynthesis"
MS09-NEUR: Ionic Flow through Membrane Channels
Organized by: Peter Bates (Michigan State University), Weishi Liu (Mathematics, U. Kansas, USA), Mingji Zhang (Mathematics, New Mexico Tech., USA) Note: this minisymposia has multiple sessions. The second session is MS03-NEUR.
- Tom DeCoursey (Department of Physiology & Biophysics Rush University Medical Center, USA) "Proton Selective Conduction Through hHV1, the Human Voltage-gated Proton Channel"
- Mingji Zhang (Mathematics, New Mexico Tech., USA) "Competition between Cations via Classical Poisson–Nernst–Planck Models with Small Permanent Charges"
- Hamid Mofidi (Mathematics, U. Iowa, USA) "Effects of ion size on current and fluxes via hard-sphere PNP models"
- Weishi Liu (Mathematics, U. Kansas, USA) "Permanent charge effects on ionic flow"
MS09-ONCO: Recent development in mathematical oncology in Asia and Australia
Organized by: Yangjin Kim (Konkuk University, Korea, Republic of), Eunjung Kim (Korea Institute of Science and Technology, Korea) Note: this minisymposia has multiple sessions. The second session is MS15-ONCO.
- Shinji Nakaoka (Faculty of Advanced Life Science, Hokkaido University, Japan) "A computational pseudo-tracking method for cancer progression by microbiome data"
- Aurelio A. de Los Reyes V (University of the Philippines Diliman, Philippines) "Polytherapeutic strategies in cancer treatment"
- Eunjung Kim (Korea Institute of Science and Technology, Korea) "Understanding the potential benefits of adaptive therapy for metastatic melanoma"
- Masud MA (Korea Institute of Science and Technology, Korea) "The impact of spatial heterogeneity on treatment response"