The Control of the Cardiovascular System in Health and Disease
Wednesday, June 16 at 02:15am (PDT)Wednesday, June 16 at 10:15am (BST)Wednesday, June 16 06:15pm (KST)
Mette Olufsen (North Carolina State University, USA), Brian Carlson (University of Michigan, USA), Justen Geddes (North Carolina State University, USA)
The cardiovascular system delivers oxygen to all tissues in the body. The system is tightly controlled to supply oxygen under a diverse range of physiological conditions such as at rest, during postural changes, and exercise. Many studies have found that in a range of diseases, including COVID-19, cardiovascular function is compromised significantly impacting quality of life. The cardiovascular control system responds to mechanical, neural and hormonal stimuli and is difficult to study experimentally, as the system is best studied in the awake condition. Therefore, experimental measures e.g., heart rate, blood pressure, and respiration rate are typically non-invasive, and clinical invasive measures e.g., right heart catheterization, are only taken when the risk to the patient is minimal. A better understanding of how these non-invasive and low risk invasive measures can be used to quantitatively describe cardiovascular function is essential for improving diagnosis and treatment protocols. Numerous studies have used modeling to examine cardiovascular function and its control in animals and humans; however, more work is needed to translate these results to improve clinical protocols. This minisymposium focuses on exploring cardiovascular function - highlighting contributions that combine mathematical modeling, machine learning and signal processing.