Oncolytic virotherapy has emerged as a viable treatment for cancers. Although successful cancer treatments with viruses have been observed, they are few and far between. Here, we explore whether combining virotherapy with other methods of cancer treatment may lead to more robust, reliable cancer treatment. For example, cancer cells sometimes undergo mutations that allow them to develop resistance to treatment drugs. To address such a mutation, we explore the possibility of targeting drug-resistant mutants with viruses so that standard drug treatments of cancerous tumors may be used to target cancerous cells. We develop a lattice model that describes cancer tumor growth dynamics and mutant cell dynamics. We find that when mutant cells have a disadvantageous mutation, virus infection amplifies the nature of the disadvantage, with a slight caveat. When infectivity is too high, the population-level death rate is increased so that for a tumor to reach a given size, more cell divisions are necessary. This leads to the presence of more mutants than when no virus is present. We explore this nuanced system with a mean field equation and discuss how viruses used in such a way can progress cancer treatments in the future.
Wednesday, June 16 at 04:15am (PDT)Wednesday, June 16 at 12:15pm (BST)Wednesday, June 16 08:15pm (KST)
MS12-CBBS: Lattice Models and Agent-Based Models in Biology: Linking Individual Properties to Population Properties
Organized by: Bhargav Karamched (Florida State University, United States of America) Note: this minisymposia has multiple sessions. The second session is MS13-CBBS.
- Bhargav Karamched (Florida State University, United States of America) "Spatial Model of Oncolytic Virotherapy: Targeting Drug-Resistant Mutants"
- Cicely Macnamara (University of St Andrews, Scotland) " Computational modelling and simulation of tumour growth and development within a 3D heterogeneous tissue"
- Hamid Teimouri (Rice University, United States of America) "The impact of the temporal order of mutations on cancer initiation dynamics"
- Namiko Mitarai (University of Copenhagen, Denmark) "Emergence of diversity in a model ecosystem of sessile species with mutually exclusive interactions"
MS12-CDEV: Synergy between experiments and modelling in understanding morphogenetic processes
Organized by: Alessandra Bonfanti (Sainsbury Laboratory University of Cambridge, United Kingdom), Alexandre Kabla (University of Cambridge, United Kingdom)
- Shiladitya Banerjee (Carnegie Mellon University, USA) "Cell-scale modeling of epithelial morphogenesis using quantitative theory and optogenetics"
- Jean-François Rupprecht (CNRS & Turing Centre for Living Systems Group Leader, Aix-Marseille University., France) "Epithelial tissues flows over hills, valleys and around potholes"
- Alan Lowe (University College London, UK) "Learning the rules of cell competition"
- Pasquale Ciarletta (Politecnico di Milano, Italy) "Pattern formation and self-organization during cancer cell budding in-vitro"
MS12-DDMB: Mathematical Modeling of Protein Dynamics
Organized by: Suzanne S. SINDI (University of California, Merced, USA) Note: this minisymposia has multiple sessions. The second session is MS11-DDMB.
- Human REZAEI (INRAE, Jouy-en-Josas, FRANCE) "to be announced"
- Maria Carla TESI (Universitá di Bologna, ITALY) "The synergistic interplay between two proteins: a mathematical model for Alzheimer's disease"
- Léon Matar TINE (Université de Lyon, FRANCE) "Analysis and numerical simulations of a reaction-diffusion model with fixed active bodies: Application to Alzheimer's disease."
- Laurent PUJO-MENJOUET (Université de Lyon, FRANCE) "Alzheimer and Prion: a dangerous liaison"
MS12-IMMU: Mathematical modelling of the coronavirus disease
Organized by: Alexey Tokarev (Рeoples’ Friendship University of Russia, Russia)
- Vitaly Volpert (CNRS, University Lyon, France) "Introduction to the pathophysiology of the coronavirus disease"
- Anass Bouchnita (Department of Integrative Biology, University of Texas at Austin, USA) "Multiscale modelling of SARS-CoV-2 infection to study the role of innate and adaptive immune responses in healthy and immunocompromised individuals"
- Bogdan Kazmierczak (Institute of Fundamental Technological Research, Polish Academy of Sciences, Poland) "Infection spreading in cell culture as a reaction-diffusion wave"
- Alexey Tokarev (S.M. Nikolskii Mathematical Institute, Рeoples’ Friendship University of Russia (RUDN University), Russia) "Nonlinear dynamics in the homogeneous model of immune responses to SARS-CoV-2 virus"
MS12-MEPI: Modeling containment and mitigation of COVID-19: experiences from different countries worldwide
Organized by: Andrei Akhmetzhanov (National Taiwan University College of Public Health, Taiwan), Natalie Linton (Hokkaido University, Japan) Note: this minisymposia has multiple sessions. The second session is MS15-MEPI.
- Michael Hochberg (Institute for Evolutionary Sciences, University of Montpellier, France) "Modeling COVID-19: Seeing the forest for the trees"
- Natalie Linton (Hokkaido University, Kyoto University, Japan) "Variation in serial interval distribution among reported cases in Japan"
- Robin Thompson (University of Warwick, U.K.) "Inferring the effectiveness of interventions during infectious disease outbreaks"
- Sumire Sorano (London School of Hygiene and Tropical Medicine, U.K.) "The impact of COVID-19 from social and gender perspectives in Japan"
MS12-MFBM: Stochastic Systems Biology: Theory and Simulation
Organized by: Jae Kyoung Kim (Department of Mathematical Sciences, KAIST, Republic of Korea), Ramon Grima (University of Edinburgh, United Kingdom) Note: this minisymposia has multiple sessions. The second session is MS11-MFBM.
- Hyukpyo Hong (Department of Mathematical Sciences, KAIST, Republic of Korea) "Inference of stochastic dynamics in biochemical reaction networks by exploiting deterministic dynamics"
- Zhou Fang (ETH Zurich, Switzerland) " Stochastic filtering for multiscale stochastic reaction networks based on hybrid approximations"
- Samuel Isaacson (Boston University, Department of Mathematics and Statistics, USA) "Stochastic Reaction-Drift-Diffusion Methods for Studying Cell Signaling"
- Brian Munsky (Colorado State University, USA) "Designing Optimal Microscopy Experiments to Harvest Single-Cell Fluctuation Information while Rejecting Image Distortion Effects"
MS12-MMPB: Dynamics of hematopoiesis in health and disease - from governing principles to clinical implications
Organized by: Peter Ashcroft (ETH Zurich, Switzerland), Tony Humphries (McGill University, Canada), Morten Andersen (Roskilde University, Denmark) Note: this minisymposia has multiple sessions. The second session is MS13-MMPB.
- Nathaniel Mon Père (Queen Mary University of London and Barts Cancer Institute, UK) "Somatic evolution in healthy hematopoietic stem cells"
- Gladys Poon (University of Cambridge, UK) "Synonymous mutations reveal genome-wide levels of positive selection in healthy tissues"
- Thomas Stiehl (RWTH Aachen University, Germany) "Relating competition in the stem cell niche to biomarkers of acute myeloid leukemia progression - Insights from mathematical modeling"
- Johnny T. Ottesen (Roskilde University, Denmark) "Dynamics of Hematological Cancer-Infection Comorbidities – an in silico study"
MS12-NEUR: The Control of the Cardiovascular System in Health and Disease
Organized by: Mette Olufsen (North Carolina State University, USA), Brian Carlson (University of Michigan, USA), Justen Geddes (North Carolina State University, USA) Note: this minisymposia has multiple sessions. The second session is MS11-NEUR.
- Brian E. Carlson (University of Michigan, Ann Arbor, MI, USA) "Using Modeling to Understand Pathophysiology in the Cardiovascular Control System"
- John S. Clemmer (Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA) "Physiological Modeling of Hypertensive Kidney Disease in African Americans"
- Peng Li (Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA) "Resting Heart Rate Complexity and All-Cause and Cardiorespiratory Mortality in a Middle-to-Older Aged, Population Cohort"
- Ashwin Belle (Fifth Eye Inc., Ann Arbor, MI, USA) "Hemodynamic Monitoring: Seeing the Unseen"
MS12-ONCO: Mathematical Oncology: From methodological studies to clinical applications
Organized by: Saskia Haupt (Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Germany), Vincent Heuveline (Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Germany), Matthias Kloor (Department of Applied Tumor Biology (ATB), Institute of Pathology, University Hospital Heidelberg, Germany) Note: this minisymposia has multiple sessions. The second session is MS11-ONCO.
- Natalia Komarova (Department of Mathematics, University of California Irvine, Irvine, California, USA) "CLL and the drug Ibrutinib: modeling and clinical applications"
- Johannes G Reiter (Canary Center for Cancer Early Detection, Department of Radiology, Stanford University, California, USA) "Minimal intermetastatic heterogeneity"
- Kamila Naxerova (Center for Systems Biology, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA) "On the evolutionary history of metastatic cancer"
- Saskia Haupt (Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Germany) "A computational model for investigating the evolution of colonic crypts during Lynch syndrome carcinogenesis"