Morphoelasticity, an emerging area of continuum mechanics, can describe the large strains of organogenesis. We apply this framework modeling lung branching. Many previous models of lung branching morphogenesis were focused on the complex morphogen signaling systems and either omit explicit modeling of shape change, or model shape change by moving a surface normal to itself without explicit mechanics equations. Previous models have shown that morphogen flux distribution corresponds to the location of branching, and that this distribution is reliant on local geometry. We explicitly modeled both the morphogen signaling and the resulting growth dependent on the calculated morphogen flux distribution, in a novel application of morphoelastic shell modeling for lung growth. We concluded that local geometry affects the resulting shape change. Specifically, we observed tubule lengthening for all local geometries and shouldering for epithelium of elliptical cross-section. We also observed that the thickness of the epithelium affects the resulting shape change. This modeling approach of shell mechanics combined with morphoelasticity allowed us to test complex hypotheses on growth and can be generalized for many other organ systems.
Wednesday, June 16 at 05:45pm (PDT)Thursday, June 17 at 01:45am (BST)Thursday, June 17 09:45am (KST)
MS15-CBBS: Understanding lung function and disease through mathematical modeling and experiment
Organized by: Uduak George (San Diego State University, United States), Mona Eskandari (University of California Riverside, United Staes) Note: this minisymposia has multiple sessions. The second session is MS14-CBBS.
- Ariel Nikas (Emory University, School of Medicine, United States) "Using morphoelasticity to model early lung branching"
- Mona Eskandari (University of California at Riverside, United States) "Characterizing pulmonary mechanics using an experimental-computational framework"
- Ramana Pidaparti (University Of Georgia Athens, United States) "Computational Models and Informatics for Lung Inflammation and Aging"
- Uduak George (San Diego State University, United States) "Mathematical modeling of fibroblast growth factor expression in developing lungs"
MS15-CDEV: Modeling of energy-utilizing biopolymers
Organized by: Holly Goodson (University of Notre dame, USA), Shant Mahserejian (Pacific Northwest National Laboratory, USA)
- Jared Scripture (University of Notre Dame, USA) "Quantification of Microtubule Stutters: Dynamic Instability Behaviors that are Strongly Associated with Catastrophe"
- Diana White (Clarkson University, USA) "Modelling microtubule dynamic instability: microtubule growth, shortening and pausing"
- Kimberly Weirich (Clemson University, USA) "Self-organization and shape change in active biopolymer droplets"
- Sidney Shaw (Indiana University, USA) "Extracting local polymer dynamics for global cellular models."
MS15-DDMB: Modelling and Methods in Mathematical Biology
Organized by: Anthony Kearsley (National Institute of Standards and Technology, USA)
- Julia Seilert (Department of Food Process Engineering, Technische Universität Berlin, Germany) "Revisiting a model to predict pure triglyceride thermodynamic properties: parameter optimization and performance"
- Adarsh Kumbhari (School of Mathematics and Statistics, University of Sydney, Australia) " Modeling PD-L1 inside the tumor microenvironment"
- Danielle Brager (National Institute of Standards and Technology, USA) "Mathematically Investigating Retinitis Pigmentosa"
- Anca Radulescu (State University of New York at New Paltz, USA) "Estimating glutamate transporter surface density in mouse hippocampal astrocytes"
MS15-EVOP: Modeling and Simulation of Hydrodynamics in Cell Biology
Organized by: Thomas Fai (Brandeis University, USA), Ying Zhang (Brandeis University, USA)
- Paul Atzberger (UC Santa Barbara, USA) "Surface Fluctuating Hydrodynamics Approaches for Proteins Kinetics and Transport within Curved Lipid Bilayer Membranes"
- Luoding Zhu (Indiana U-Purdue U Indianapolis, USA) "Modeling and simulation of fluid flow over osteocyte"
- Nicholas Chisholm (Worcester Polytechnic Institute, USA) "Novel Regularized Stokeslets for Biological Fluid Flow Problems"
- Thomas Fai (Brandeis University, USA) "Hydrodynamics of cell suspensions near walls"
MS15-IMMU: Modelling the combination of vaccination and Non-pharmaceutical interventions strategies to control COVID-19 propagation
Organized by: Jacques Bélair (Université de Montréal, Canada) & Elena Aruffo (York University, Canada)
- Matthew Betti (Mount Allison University) "Combining data forecasting with scenario-based modeling for insights into a rapidly changing outbreak situation"
- Marina Mancuso (Arizona State University) "Will Cross-Immunity Protect the Community Against COVID-19 Variants ?"
- Elena Aruffo (York University) "Vaccination rollout and relaxation of non-pharmaceutical interventions: a combined approach"
- Nicola Perra (University of Greenwich) "Modelling the COVID-19 pandemic at different spatio-temporal scales"
MS15-MEPI: Modeling containment and mitigation of COVID-19: experiences from different countries worldwide
Organized by: Andrei Akhmetzhanov (National Taiwan University College of Public Health, Taiwan), Natalie Linton (Hokkaido University, Japan) Note: this minisymposia has multiple sessions. The second session is MS12-MEPI.
- Jonathan Dushoff (McMaster University, Canada) "Defining, estimating and applying transmission-interval distributions"
- Sarah Kada (Centers for Disease Control and Prevention (CDC), U.S.A.) "Early assessment of SARS-CoV-2 controllability with contribution of asymptomatic and pre-symptomatic individuals"
- Hao-Yuan Cheng (Epidemic Intelligence Center, Taiwan CDC, Taiwan) "Experience of COVID-19 elimination in Taiwan"
- Ta-Chou Ng (National Taiwan University, Taiwan) "Comparison of Estimated Effectiveness of Case-Based and Population-Based Interventions on COVID-19 Containment in Taiwan"
MS15-MFBM: Emergent behavior across scales: locomotion, mixing, and collective motion in active swimmers
Organized by: Robert Guy (University of California Davis, United States), Arvind Gopinath (University of California Merced, United States) Note: this minisymposia has multiple sessions. The second session is MS09-MFBM.
- Maxime Theillard (University of California Merced, United States) "Multi-scale multi-species modeling of emergent flows and active mixing in confined bacterial swarms"
- Paulo Arratia (University of Pennsylvania, United States) "Bacteria hinder stretching and large-scale transport in time-periodic flows"
- Bin Liu (University of California Merced, United States) "Anomalous size-dependent active transport in structured environments"
- Nick Cogan (Florida State University, United States) "Modeling the Origin of Life Reaction in Microfluidic Chambers"
MS15-MMPB: Fluid dynamics of swimming organisms
Organized by: Laura Miller (University of Arizona, U.S.A.), Arvind Santhanakrishnan (Oklahoma State University, U.S.A.)
- Silas Alben (University of Michigan, U.S.A.) "Collective locomotion of two-dimensional lattices of flapping plates"
- Anand Oza (Department of Mathematical Sciences, New Jersey Institute of Technology, U.S.A) "Coarse-grained models for schooling swimmers"
- Arvind Santhanakrishnan (Oklahoma State University, U.S.A.) "Hydrodynamics of multi-appendage metachronal swimming"
- Alexander Hoover (The University of Akron, U.S.A.) "Emergent metachronal asymmetries in a tension-driven, fluid-structure interaction model of tomopterid parapodia"
MS15-NEUR: Multi-scale Physiological Systems
Organized by: Saeed Farjami (University of Surrey, United Kingdom), Anmar Khadra (McGill University, Canada) Note: this minisymposia has multiple sessions. The second session is MS14-NEUR.
- Anmar Khadra (McGill University, Canada) "Characterizing the spatiotemporal patterns produced by an excitable fish keratocyte model"
- Theodore Vo (Monash University, Australia) "Big Ducks in the Heart"
- Sushmita John (University of Pittsburgh, USA) "Transitions in neuronal bursting types"
- André Longtin (University of Ottawa, Canada) "Multi-delay control, communication and complexity"
MS15-ONCO: Recent development in mathematical oncology in Asia and Australia
Organized by: Yangjin Kim (Konkuk University, Korea, Republic of), Eunjung Kim (Korea Institute of Science and Technology, Korea) Note: this minisymposia has multiple sessions. The second session is MS09-ONCO.
- Dumitru Trucu (Division of Mathematics, University of Dundee, DD1 4HN, Dundee, United Kingdom) "Multiscale 3D Glioblastoma Modelling: Bulk and Leading Edge Dynamics within the Fibrous Brain Tissue"
- Peter Kim (University of Sydney, Australia) "How do viruses move? Modelling diffusion of oncolytic virus in collagen-dense tumours"
- Da Zhou (School of Mathematical Sciences, Xiamen University, China) "Cancer suppression: ingredients utilized by cellular hierarchy"
- Junho Lee (Department of Mathematics, Konkuk University, Korea) "Role of neutrophil extracellular traps in regulation of lung cancer invasion : a computational model"