Dynamics of hematopoiesis in health and disease - from governing principles to clinical implications
Wednesday, June 16 at 04:15am (PDT)Wednesday, June 16 at 12:15pm (BST)Wednesday, June 16 08:15pm (KST)
Peter Ashcroft (ETH Zurich, Switzerland), Tony Humphries (McGill University, Canada), Morten Andersen (Roskilde University, Denmark)
Blood cells dominate cell turnover in the human body. This advocates for strong regulating mechanisms of blood production (hematopoiesis). Many diseases of the hematopoietic system can be diagnosed from blood samples while the malfunction itself may be located at the less-accessible stem cell level in the bone marrow – the breeding ground for blood cells. This calls for mechanism-based mathematical modelling and analysis bridging biological knowledge and data from the stem cell level to mature blood cells. In this minisymposium the precise language of mathematics is used to formulate the governing principles of hematopoiesis. Difficult problems arise, such as including nonlinear feedback mechanisms, interaction of hematopoiesis with the immune system and dealing with heterogeneous subclone formation in the case of blood cancers. The use of mathematical modelling for diagnosis and patient-specific treatment protocols for blood malignancies will be explored.