Asymmetric cell division, where daughter cells inherit unequal amounts of specific factors, is critical for development and cell fate specification, and is implicated in disease processes such as tumour growth. In polarized cells, where specific factors are segregated to opposite ends of the cell as seen in early embryos of the nematode worm C. elegans, asymmetric cell division occurs as a result of dynein-mediated centrosome positioning along the polarity axis. Using a combination of stochastic and continuum models with experimental validation, we show that centrosome asymmetry is critical for centrosome positioning in the early C. elegans embryo, and that this asymmetry arises from differential recruitment of proteins to centrosomes during their maturation process.
Monday, June 14 at 7:45pm (PDT)Tuesday, June 15 at 03:45am (BST)Tuesday, June 15 11:45am (KST)
MS04-CDEV: Diverse quantitative approaches integrating data and modelling in development and medicine
Organized by: Adriana Dawes (Ohio State University, USA), Sungrim Seirin-Lee (Hiroshima University, Japan) Note: this minisymposia has multiple sessions. The second session is MS03-CDEV.
- Adriana Dawes (Ohio State University, USA) "The causes and consequences of centrosome asymmetry during development"
- Susanne Rafelski (Allen Institute for Cell Science, USA) "Decoding the variance in intracellular organization of human stem cells"
- Naoki Honda (email@example.com, Japan) "Data-driven hierarchical modeling of collective cell migration"
- Hiroshi Suito (Tohoku University, Japan) "Patient-specific approaches to cardiovascular diseases"
MS04-IMMU: Collaboration and calibration: modelling with experimental and clinical data
Organized by: Adriana Zanca (The University of Melbourne, Australia), Jennifer Flegg (The University of Melbourne, Australia), Helen Byrne (University of Oxford, UK) Note: this minisymposia has multiple sessions. The second session is MS03-IMMU.
- Wafaa Mansoor (Murdoch University, Australia) "Modelling hydrogen clearance in the retina"
- Vijayalakshmi Srinivasan (Auckland Bioengineering Institute, New Zealand) "3D analysis of Human placental cotyledon: a step ahead to understand feto-placental vasculature"
- Yuhuang Wu (Kirby Institute, Australia) "Predicting the composition of the HIV / SIV Reservoir and Rebounding Virus"
- Claire Miller (University of Amsterdam, Netherlands) "In silico clinical trials for acute ischemic stroke"
MS04-MEPI: Mathematical Modelling that Supported Australia and New Zealand’s COVID-19 Responses
Organized by: James Walker (The University of Melbourne, Australia)
- Rebecca Chisholm (La Trobe University, Australia) "Modelling response strategies for potential COVID-19 outbreaks in remote Australian Aboriginal communities"
- Emily Harvey (ME Research & Te Pūnaha Matatini, Aotearoa New Zealand) "Modelling COVID-19 in Aotearoa NZ on a bipartite contact network of 5 million individuals"
- Michael Plank (University of Canterbury, Aotearoa New Zealand) "Modelling the risk of re-introduction of COVID-19 from border arrivals"
- Freya Shearer (The University of Melbourne, Australia) "Supporting the Australian response to COVID-19 through model-based situational assessment"
MS04-NEUR: Hibernation and circadian rhythms: the differences and the possible interactions
Organized by: Shingo Gibo (RIKEN, Japan) and Gen Kurosawa (RIKEN, Japan)
- Elena Gracheva (Yale School of Medicine, United States of America) "Neurophysiological adaptations to the unique lifestyle in mammalian hibernators"
- Tanya Leise (Amherst College, United States of America) "Analysis of the Circadian Rhythms of Brown Bears During Winter Dormancy"
- Hsin-tzu Wang (The University of Tokyo, Japan) "Cold Ca2+ signaling for temperature compensation of circadian rhythms"
- Shingo Gibo (RIKEN iTHEMS, Japan) "Waveform analysis reveals the mechanisms for circadian rhythms and hibernation"