Morphogenesis is a precise and robust dynamic process during metazoan embryogenesis consisting of both cell proliferation and cell migration. However, unlike the progress in discovering molecular activity that regulate morphogenesis, general and extensible in silico model based on cell-level interaction has not been well established yet, especially for comprehensive reconstruction and prediction on morphological features observed in live embryo (e.g., cell shape, cell-cell contact relationship). In this talk, using Caenorhabditis elegans as model animal, we present a data-driven phase field model to simulate the morphogenesis procedure within a confined compressed eggshell. We first collected three-dimensional time-lapse (4D) cellular morphological information from the in vivo imaging experiments. Based on the developmental properties obtained, we not only successfully reconstructed the evolution of cell location, cell morphology and cell-cell contact relationship observed in real embryo, but also provided mechanical perspectives on several significant developmental events such as Wnt signaling from P2 to EMS, establishment of the three orthogonal body axes and spatial robustness against external compression.
Tuesday, June 15 at 07:45pm (PDT)Wednesday, June 16 at 03:45am (BST)Wednesday, June 16 11:45am (KST)
MS10-CBBS: Modeling and data analysis of dynamics from molecules, cells to populations
Organized by: Lei Zhang (Peking University, China) Note: this minisymposia has multiple sessions. The second session is MS09-CBBS.
- Lei Zhang (Peking University, China) "Computable Early C. elegans Embryo with a Data-driven Phase Field Model"
- Masakazu Akiyama (Meiji University, Japan) "A three-dimensional vertex dynamics model for understanding the twisting phenomenon of the hindgut of Drosophila"
- Chunhe Li (Fudan University, China) "A Dimension Reduction Approach for Energy Landscape"
- Chansoo Kim (Korea Institute of Science and Technology, Korea) "Kinetic Monte Carlo and the infectious disease dynamics with age and region"
MS10-ECOP: Spatial approaches to ecological population monitoring and management
Organized by: Tae-Soo Chon (Pusan National University/Ecology and Future Research Association, Republic of Korea), Fugo Takasu (Nara Women’s University, Japan) Note: this minisymposia has multiple sessions. The second session is MS09-ECOP.
- Hyo Gyeom Kim (Chonnam National Univ, Republic of Korea) "Importance of spatial clustering and environmental parameters on classification of the relationships between chemical composition of water body and sediment, and indices of various trophic level biotic communities in river system"
- Byungjoon Min (Chungbuk National University, Republic of Korea) "Identifying an influential spreader in epidemics on meta-population models"
- KyoungEun Lee (National Institute of Ecology, Republic of Korea) "Network analysis for predicting invasive alien species dispersal in a novel cell-based metapopulation model"
- Fugo Takasu (Nara Women’s Univ, Japan) "Estimation of spatial interaction kernel from time series data - a point pattern approach"
MS10-EVOP: The Study of Diffusive Dispersal in Population Dynamics
Organized by: Chiu-Yen Kao (Claremont McKenna College, United States), Bo Zhang (Oklahoma State University, United States) Note: this minisymposia has multiple sessions. The second session is MS08-EVOP. The third session is MS09-EVOP.
- Seyyed Abbas Mohammadi (Yasouj University, Iran) "Optimal Chemotherapy for Brain Tumor Growth in a Reaction-Diffusion Model"
- Daozhou Gao (Shanghai Normal University, China) "Effects of asymmetric dispersal on total biomass in a two-patch logistic model"
- Alfonso Ruiz-Herrera (University of Oviedo, Spain) "Network Topology vs. Spatial Scale of Movement in Trophic Metacommunities"
- Xiaoqing He (East China Normal University, China) "On the effects of carrying capacity of intrinsic growth rate on single and multiple species in spatially heterogeneous environments"
MS10-IMMU: Within-host modelling of SARS-CoV-2
Organized by: Thomas Hillen (University of Alberta, Canada), Carlos Contreras (University of Alberta, Canada) Note: this minisymposia has multiple sessions. The second session is MS09-IMMU.
- Suzan Farhang Sardroodi (York University, Canada) "Analysis of host immunological response of adenovirus-based Covid-19 vaccines"
- Dominik Wodarz (UC Irvine, USA) "The impact of viral variants on the immune response during COVID-19"
- Carlos Contreras (University of Alberta, Canada) "Personalized Virus Load Curves of SARS-CoV-2 Infection"
- Jane Heffernan (York University, Canada) " A multi-scale model for SARS-CoV-2 infection"
MS10-MMPB: Models and Computations for Studying Biofluid Applications
Organized by: Zhiliang Xu (Univeristy of Notre Dame, USA), Giordano Tierra (University of North Texas, USA), Shixin Xu (Duke Kunshan University) Note: this minisymposia has multiple sessions. The second session is MS16-MMPB.
- Qi Wang (U of South Carolina, USA) "A Phase Field Embedding Method for Flow-Active Particle Interactions"
- Jia Zhao (Utah State University, USA) "Partial demixing of RNA-protein complexes leads to intra-droplet patterning in phase-separated biological condensates"
- Xinfeng Liu (Department of Mathematics, University of South Carolina, USA) "Mathematical modeling and computational investigation of heterogeneity in breast cancer cells"
- Isaac Klapper (Temple University, USA) "Modeling Metabolism in Microbial Biofilms"