Despite its prevalence in the population, the causes of asthma remain poorly understood. Airway hyperresponsiveness causes airway constriction at low doses of agonist which is thought to activate cytokines, such as Transforming Growth Factor β (TGF-β). TGF-β is thought to play a key role in promoting airway remodelling, which in turn could exaggerate hyperresponsiveness in a positive feedback loop; however, it is not clear what comes first. To begin to elucidate this, our research combines mathematical models of contracting airways with ex vivo precision-cut lung-slice (PCLS) stretching experiments to study stress-driven TGF-β activation in asthmatic airways. In this talk, we describe our mathematical model that couples subcellular mechanotransductive signalling pathways to nonlinear hyperelastic models of airway mechanics to predict the levels of TGF-β activation in different experimental conditions. We account for TGF-β-mediated contraction of the airway smooth muscle and the subsequent change in effective mechanical properties of the PCLS as TGF-β activation progresses. In agreement with the experimental results, we find that TGF-β activation increases as the airway deforms with imposed stretch. Our work shows that airway contraction, induced by active TGF-β signalling, in conjunction with airway wall stiffening generates stress differences across the airway wall and consequently initiates a positive feedback loop of TGF-β activation. Our work gives access to the highly complex stress distribution within the airway wall and surrounding parenchyma that can be used to investigate the effects of contractile heterogeneity and examine airway wall structure. This integrated study provides information that is of vital importance in interpreting PCLS experiments that seek to clarify the mechanochemical mechanisms underpinning TGF-β activation, a key aspect of the disease, that has only recently received attention.
Wednesday, June 16 at 11:30am (PDT)Wednesday, June 16 at 07:30pm (BST)Thursday, June 17 03:30am (KST)
MS14-CBBS: Understanding lung function and disease through mathematical modeling and experiment
Organized by: Uduak George (San Diego State University, United States), Mona Eskandari (University of California Riverside, United Staes) Note: this minisymposia has multiple sessions. The second session is MS15-CBBS.
- Hannah Pybus (School of Mathematical Sciences, University of Nottingham, United Kingdom) "Airway constriction in asthma - is it the chicken or the egg?"
- Ashley Schwartz (Computational Science Research Center, San Diego State University, United States) "New metrics for quantifying the spatial inhomogeneity of abnormal fluid in MR images of cystic fibrosis lungs"
- Nourridine Siewe (Rochester Institute of Technology, United States) "A Mathematical Model of the Role of MIF in Severe Malarial Anemia: What Happens in TB"
- Blessing Emerenini (Rochester Institute of Technology, United States) "Trends in the mathematical modeling of Bacteria-Phage combat in lung treatment"
MS14-CDEV: Combining modeling and inference in cell biology
Organized by: Maria-Veronica Ciocanel (Duke University, United States), John Nardini (North Carolina State University, United States) Note: this minisymposia has multiple sessions. The second session is MS13-CDEV.
- Keisha Cook (Tulane University, United States) "Single Particle Tracking with applications to lysosome transport"
- Christopher Miles (New York University, United States) "Stochastic organization of the mitotic spindle from spatiotemporal trajectories"
- Ruth Baker (University of Oxford, United Kingdom) "Quantifying the impact of electric fields on single-cell motility"
- Carter Jameson (North Carolina State University, United States) "Parameterizing agent based models of collective cell migration using topological information"
MS14-DDMB: Numerical methods in biomedical sciences
Organized by: Yifan Wang (University of California, Irvine, USA), Pejman Sanaei (New York Institute of Technology, USA) Note: this minisymposia has multiple sessions. The second session is MS13-DDMB.
- Sudhir Pathak (email@example.com, USA) "Computational Modeling of the human brain tissue, Estimation and Quantifying tissue type"
- Yuchi Qiu (Michigan State University, USA) "Learning biomolecules in mutagenesis via topological and geometric modeling"
- Yu (Andy) Huang (Memorial Sloan Kettering Cancer Center, USA) "Computational Models of Transcranial Electrical Stimulation: Methodology, Optimization and Validations"
- Mac Hyman (Tulane University, USA) "A Bipartite Network Sexual Transmission Model to Inform Public Health Efforts for Controlling the Spread of Chlamydia Trachomatis"
MS14-ECOP: Mathematical modeling of water resources
Organized by: Claudia Mazza Dias (UFFRJ - Universidade Federal Rural do Rio de Janeiro, Brazil), Anna Regina Corbo Costa (Cefet/RJ - Centro Federal de Educação Tecnológica Celso Suckow da Fonseca, Brazil), José Carlos Rubianes Silva (Cefet/RJ - Centro Federal de Educação Tecnológica Celso Suckow da Fonseca, Brazil), Kymie Karina S Saito (UFFRJ - Universidade Federal Rural do Rio de Janeiro, Brazil), Dayse Haime Pastore (CEFET-RJ)
- Fernando Momo (Instituto de Ciencias. Universidad Nacional de General Sarmiento, Argentina) "How to convince policymakers that uncertainty exists: do mathematical models help or confuse?"
- João Frederico da Costa Azevedo Meyer (UNICAMP - Universidade Estadual de Campinas, Brazil) "Water quality and environmental and ecological risks"
- Raquel Figueira (Hubz, Brazil) "Populacional Density Model of Limnoperna Fortunei for Três Irmãos Hydroelectric – São Paulo, Brasil"
- Renato Nascimento Elias (Civil Engineering Department at Federal University or Rio de Janeiro • PEC/COPPE/UFRJ, Brazil) "3D Numerical Modeling of Dambreak Problems using Finite Element Method"
MS14-EDUC: Recent Perspectives on Mathematical Education
Organized by: Stacey Smith? (The University of Ottawa, Canada) Note: this minisymposia has multiple sessions. The second session is MS13-EDUC.
- Elissa Schwartz (Washington State University, USA) "Remedying the Leaky Pipeline"
- Suzanne Lenhart (University of Tennessee at Knoxville, USA) "BioCalculus Assessment Tool"
- Amanda Laubmeier ( Texas Tech University, USA) "Application-driven projects in differential equation and modelling courses"
- Stacey Smith? (The University of Ottawa, Canada) "Teaching While Trans"
MS14-EVOP: Going backward in time with the coalescent and other ancestral structures
Organized by: Fernando Cordero (Bielefeld University, Germany), Sebastian Hummel (Bielefeld University, Germany)
- Cornelia Pokalyuk (Goethe University Frankfurt, Institute for Mathematics, Germany) "Haldane’s formula in Cannings models with moderate selection"
- Maite Wilke Berenguer (Humboldt-Universität zu Berlin, Germany) "Can dormancy induce skewed offspring distributions?"
- Airam Blancas (Departamento de Estadística, ITAM, Mexico) "A coalescent model with recombination and population structure"
- Dario Spanò (University of Warwick, England) "Asymptotic genealogies for interacting particle systems"
MS14-IMMU: Immunobiology and Infection Subgroup mini-symposium
Organized by: Stanca Ciupe (Virginia Tech, United States), Jessica Conway (Penn State University, USA), Amber Smith (University of Tennessee Health Science Center, USA), Jonathan Forde (Hobart and William Smith Colleges, USA) Note: this minisymposia has multiple sessions. The second session is MS13-IMMU.
- Ivan Ramirez-Zuniga (University of Tennessee Health Science Center, USA) "A data-driven mathematical model of the role of energy in sepsis"
- Sarah Minucci (Virginia Commonwealth University, USA) "Mathematical modeling of ventilator-induced lung inflammation"
- Julia Arciero (Indiana University-Purdue University Indianapolis, USA) "Modeling novel immunoregulatory treatments for transplant patients"
- Josua Aponte-Serrano (Indiana University, USA) "Integrating Validated Models of Viral Replication and Interferon Signaling into a Multi-Scale Spatial Framework to Identify Key Factors of Viral Infection Dynamics"
MS14-MEPI: Celebrating Dr. Ngwa's 55th birthday with talks honoring his mathematical modeling work including malaria mosquitoes.
Organized by: Miranda Teboh-Ewungkem (Lehigh University, United States), Calistus N. Ngonghala, (University of Florida, Gainsville, FL, United States), Jude D. Kong (York University, Toronto, ON, Canada,, Canada) Note: this minisymposia has multiple sessions. The second session is MS07-MEPI.
- Ian Frigaard (University of British Columbia, Canada) "Yield stress fluids and G.A. Ngwa"
- Abba B. Gumel (Arizona State University, School of Mathematical and Statistical Sciences, United States) "Mathematics of population biology of malaria mosquitoes and disease: a genetic-epidemiology modeling framework"
- Gwendolyn B. Fru (University of Buea, Cameroon) "Mathematical modelling of the pharmacokinetics of antimalarial drugs under different treatment regimes"
- Kristan Alexander Schneider (Hochschule Mittweida, University of Applied Sciences, Germany) "Modelling COVID-19 in Africa"
MS14-MFBM: Data-driven methods for biological modeling in industry
Organized by: Kevin Flores (North Carolina State University, USA) Note: this minisymposia has multiple sessions. The second session is MS13-MFBM.
- Richard Allen (Quantitative Systems Pharmacology, Early Clinical Development, Pfizer Worldwide Research Development and Medical, USA) "Analyzing and Predicting Clinical Trial Data with Systems Modeling"
- Florencio Serrano Castillo (Clinical Pharmacology, Modelling and Simulations, Amgen Inc., USA) "Dosing guidance optimization, leveraging real world heterogeneity to forecast clinical biomarker response"
- Zackary Kenz (DILIsym Services, a Simulations Plus Company, USA) "Quantitative Systems Pharmacology Modeling of Fibrotic Diseases"
- Anna Neely (TigerRisk Partners, USA) "Estimating the growing risk of severe thunderstorms"
MS14-MMPB: Deterministic and stochastic models for complex cardiovascular phenomena
Organized by: Martina Bukac (University of Notre Dame, United States), Daniele Schiavazzi (University of Notre Dame, United States) Note: this minisymposia has multiple sessions. The second session is MS20-MMPB.
- Suncica Canic (University of California, Berkeley, United States) "Computational design of a bioartificial pancreas"
- Philipp Milović (University of Zagreb, Croatia) "A block-coupled finite volume solver for analysis of large strain in incompressible hyperelastic materials"
- Paolo Zunino (Politecnico di Milano, Italy) "A meso-scale computational model for micro-vascular oxygen transfer"
- Rana Zakerzadeh (Duquesne University, United States) "The Role of Intraluminal Thrombus on the Vessel Wall Oxygen Starvation"
MS14-NEUR: Multi-scale Physiological Systems
Organized by: Saeed Farjami (University of Surrey, United Kingdom), Anmar Khadra (McGill University, Canada) Note: this minisymposia has multiple sessions. The second session is MS15-NEUR.
- Saeed Farjami (University of Surrey, United Kingdom) "Non-sequential Spike Adding in Cerebellar Stellate Cells"
- Michael Forrester (University of Nottingham, United Kingdom) "Using a multiscale next-generation neural-mass model to fit neuroimaging data"
- Victoria Booth (University of Michigan, USA) "Dynamics and bifurcations of sleep-wake behavior"
- Sue Ann Campbell (University of Waterloo, Canada) "Time delays may enhance or impede synchronization in brain networks"
MS14-ONCO: Integrating quantitative imaging and mechanistic modeling to characterize tumor growth and therapeutic response
Organized by: Guillermo Lorenzo (University of Pavia, Italy), David Hormuth (The University of Texas at Austin, US), Angela Jarrett (The University of Texas at Austin, US), Thomas Yankeelov (The University of Texas at Austin, US) Note: this minisymposia has multiple sessions. The second session is MS20-ONCO.
- Andrea Gardner (The University of Texas at Austin, US) "Quantification of interactions between epithelial-like and mesenchymal-like subpopulations in a triple-negative breast cancer cell line ecosystem"
- Haley Bowers (Wake Forest School of Medicine, US) "Image Data-Driven Biophysical Mathematical Model Based Characterization of Multicellular Tumor Spheroids"
- Anum Kazerouni (University of Washington, US) "Characterizing tumor heterogeneity using quantitative MRI habitats in breast cancer in vivo"
- David Hormuth (The University of Texas at Austin, US) "Image-driven modeling of radiation therapy response in gliomas"