Upon nitrogen starvation, Schizosaccharomyces pombe (fission yeast) exits the mitotic cell cycle and becomes irreversibly committed to the completion of the meiosis program. In meiosis, DNA replication (S-phase) is followed by two successive rounds of cell divisions (Meiosis I and Meiosis II) without intermediate interphase. In this work, we developed a comprehensive model of the entire meiotic cell cycle, which couples exit from mitosis to meiotic commitment and progression under nitrogen starvation. This network was assembled from several experimental observations in the literature for meiotic cell divisions and exit. The core of the regulatory network is the regulation of cyclin-dependent kinase (Cdk) 1 and anaphase-promoting complex or cyclosome (APC/C) by meiosis-specific factors. The network was translated into a set of ordinary differential equations to simulate the dynamics of meiotic progression. We also performed one and two-parameter bifurcations to study the role of different feedback loops in meiosis. The model accounts for about 60 experimental situations including single and multiple mutations and demonstrates the control strategy involving multiple feedback loops to yield two successive division cycles. The model serves as a key tool for experimentalists to perform in silico mutations and test the hypothesis.
Monday, June 14 at 11:30pm (PDT)Tuesday, June 15 at 07:30am (BST)Tuesday, June 15 03:30pm (KST)
CDEV CDEV-10 (Session: PS01)
Atchuta Srinivas Duddu
Indian Institute of Science
"Modelling epigenetic feedback in gene regulatory network consisting of three mutually inhibiting transcription factors"
CDEV CDEV-4 (Session: PS01)
Sathvik Sanjeev Buggana
CCNSB, IIIT Hyderabad
"Modeling the liver circadian clock control by nutrients"
CDEV CDEV-8 (Session: PS01)
Luxembourg Centre for Systems Biomedicine, University of Luxembourg
"Energetic cost of the cross-talk between calcium dynamics and mitochondrial metabolism"
CDEV CDEV-9 (Session: PS01)
Md Hamidul Islam
Lecturer, Department of Applied Mathematics, University of Rajshahi, Rajshahi-6205, Bangladesh
"Modelling the Host Immune Response to Primary Dengue Infection"
MEPI MEPI-12 (Session: PS01)
Dimitris A. Goussis
"Time-scale analysis of population dynamics models for the COVID-19 pandemic"
MEPI MEPI-4 (Session: PS01)
Technical University of Munich
"How long is long enough? The impact of the contact tracing interval"
MEPI MEPI-5 (Session: PS01)
Sheryl Grace Buenaventura
Center for Applied Modeling, Data Analytics, and Bioinformatics for Decision-Support Systems in Health (AMDABIDS) - University of the Philippines Mindanao
"Understanding COVID-19 spread in the National Capital Region, Philippines using Genomic Sequences: A Phylodynamic Investigation"
MEPI MEPI-8 (Session: PS01)
University of Edinburgh
"Integrating sewage and hospital-based surveillance data on antimicrobial resistance: resistance type affects community resistance patterns"
MEPI MEPI-9 (Session: PS01)
Woldegebriel Assefa Woldegerima
Postdoc Research fellow; University of Pretoria, South Africa
"Mathematical assessment of the impact of human-antibodies during the within-mosquito dynamics of Plasmodium falciparum parasites"
ONCO ONCO-10 (Session: PS01)
University of Exeter
"Population Scale Spatio-Structural Modelling of Directed Cancer Invasion"
ONCO ONCO-6 (Session: PS01)
School of Mathematics and Statistics, University of St Andrews, St Andrews, Scotland, UK.
"Mathematical modelling quantifies ERK-activity in response to vertical inhibition of the BRAFV600E-MEK-ERK cascade in melanoma"
ONCO ONCO-7 (Session: PS01)
Integrated Mathematical Oncology, Moffitt Cancer Center; Intestinal Stem Cell Biology Lab, Wellcome Centre for Human Genetics, University of Oxford
"Reconstructing Contemporary Human Stem Cell Dynamics with Oscillatory Molecular Clocks"